Evidence map›Paper›PMID 42041596›Full record

ArticleCells2026

Effects of Age on Intervertebral Disc Tissue Morphology and Gene Expression in the ADAM8-Inactivation Mouse.

Lutian Yao, Huan Wang, Zuozhen Tian, Frances S Shofer, Ling Qin, Yejia Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lutian YaoDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0652-2075
Huan WangDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zuozhen TianPhysical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Frances S ShoferDepartment of Emergency Medicine, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, PA 19104, USA.
Ling QinDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yejia ZhangPhysical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7484-8800

Funding

Inhibition of TNF-alpha Signaling to Reduce Intervertebral Disc InflammationR21AR078386 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2021 to 2022
$383k
National Institute of health, USA AR078386NIAMS NIH HHS R21 AR078386
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADAM ProteinsAgingGene Expression RegulationIntervertebral DiscMembrane ProteinsAge FactorsAnimalsAntigens, CDMaleMiceMice, Inbred C57BLAdam8 protein, mouseADAM ProteinsAntigens, CDMembrane ProteinsADAM8ageinactivationinflammationinjuryintervertebral disc

Identifiers

PMID42041596
PMCPMC13114854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.