ArticleCells2026
Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids.
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Organoid technology is critical for studying human brain development, but existing single-organoid culture systems fail to simulate inter-organ interactions (e.g., optic vesicle-brain) in embryogenesis. This study aimed to establish a more comprehensive in vitro model for early neurodevelopment. We established standardized protocols for cerebral organoids and optic vesicle-containing brain organoids (OVB-organoids), and performed multiscale analyses using immunofluorescence and transcriptomics to compare the two models. Key differences in cellular composition, structure, function and development were found; OVB-organoids better simulated early retinal development, visual-related structures/functions, with specific VSX2 expression and consistent transcriptomic profiles. OVB-organoids are an improved model for early neurodevelopment, providing a reliable basis for exploring eye-brain coordinated development mechanisms and having broad applications in developmental biology, disease research and personalized healthcare.
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