Evidence map›Paper›PMID 42041566›Full record

ArticleCells2026

The TLR10-Vitamin D Axis Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells In Vitro.

Anna Stierschneider, Benjamin Neuditschko, Isabella Fischer, Esther Hellmann, Daniel Zimmermann, Katerina Prohaska, Lisa Milchram, Franz Herzog, Christoph Wiesner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna StierschneiderInstitute Biotechnology, IMC Krems University of Applied Sciences, 3500 Krems, Austria.ORCID 0000-0002-6963-8956
Benjamin NeuditschkoInstitute Krems Bioanalytics, IMC Krems University of Applied Sciences, 3500 Krems, Austria.ORCID 0000-0002-7024-7493
Isabella FischerInstitute Biotechnology, IMC Krems University of Applied Sciences, 3500 Krems, Austria.ORCID 0009-0003-1288-6718
Esther HellmannInstitute Biotechnology, IMC Krems University of Applied Sciences, 3500 Krems, Austria.
Daniel ZimmermannInstitute Biotechnology, IMC Krems University of Applied Sciences, 3500 Krems, Austria.ORCID 0009-0008-7938-5914
Katerina ProhaskaInstitute of Biotechnology & Analytics, Biotech Campus Tulln, University of Applied Sciences Wiener Neustadt, 3400 Tulln, Austria.ORCID 0000-0001-5982-8521
Lisa MilchramInstitute Krems Bioanalytics, IMC Krems University of Applied Sciences, 3500 Krems, Austria.
Franz HerzogInstitute Krems Bioanalytics, IMC Krems University of Applied Sciences, 3500 Krems, Austria.
Christoph WiesnerInstitute Biotechnology, IMC Krems University of Applied Sciences, 3500 Krems, Austria.ORCID 0000-0002-3281-0695

Funding

Austrian Research Promotion Agency 45624401Austrian Research Promotion Agency 880720FWF Austrian Science Fund DFH-54-BFWF Austrian Science Fund ESP 547-BLower Austria Research Funding Agency (GFF NÖ) GLF21-1-019
6 · The paper itself

Abstract

Bone regeneration requires tight coordination between mesenchymal stem cells (MSCs), immune signaling, and extracellular matrix remodeling. Yet, how atypical immune receptors contribute to this process remains unclear. Here, we identify Toll-like receptor 10 (TLR10) as a key regulator of osteogenic differentiation in human adipose-derived MSCs. Herein, ASC/TERT1 MSCs were engineered to overexpress or silence TLR10 using lentiviral vectors, and osteogenic differentiation (0-14 days) was assessed by metabolic assays-RT-qPCR of

Indexed as

Cell DifferentiationMesenchymal Stem CellsOsteogenesisVitamin DExtracellular MatrixHumansOsteoblastsSignal TransductionVitamin Dcalcitriolmesenchymal stem cellsosteogenic differentiationtoll-like receptor 10

Identifiers

PMID42041566
PMCPMC13115012

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.