Evidence map›Paper›PMID 42041563›Full record

ArticleCells2026

Crypt-Level Tight Junction Remodeling Is Associated with Disease Course and Clinical Outcomes in Inflammatory Bowel Disease.

Efthymios P Tsounis, Christina Geramoutsou, Ploutarchos Pastras, Ioanna Aggeletopoulou, Pinelopi Bosgana, Theoni Lourida, Georgia Diamantopoulou, Sofia Ritsatou, Efthymios Koniaris, Gerassimos J Mantzaris and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Efthymios P TsounisDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-2797-5070
Christina GeramoutsouDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504 Patras, Greece.
Ploutarchos PastrasDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0009-0001-7790-7845
Ioanna AggeletopoulouDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-4489-1485
Pinelopi BosganaDepartment of Pathology, School of Medicine, University of Patras, 26504 Patras, Greece.
Theoni LouridaDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-1332-6013
Georgia DiamantopoulouDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.
Sofia RitsatouDepartment of Pathology-Anatomy, Hippocration Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Efthymios KoniarisDepartment of Pathology-Anatomy, Hippocration Hospital of Athens, Athens Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0009-0005-7804-1472
Gerassimos J MantzarisDepartment of Gastroenterology, White Cross Hospital, 11528 Athens, Greece.ORCID 0000-0002-5302-5450
Vasiliki ZolotaDepartment of Pathology, School of Medicine, University of Patras, 26504 Patras, Greece.
Stelios F AssimakopoulosDivision of Infectious Diseases, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-6901-3681
Vasiliki BravouDepartment of Anatomy-Histology-Embryology, Medical School, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-4635-0204
Konstantinos ThomopoulosDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.
Georgios TheocharisDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.
Christos TriantosDivision of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0003-3094-8209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal barrier dysfunction is a hallmark of inflammatory bowel disease (IBD), yet the clinical significance of tight junction (TJ) remodeling remains unclear. We investigated whether alterations in the expression and localization of key TJ proteins are associated with disease activity and clinical outcomes in IBD.

methodsThis retrospective, single-center study included patients with Crohn's disease (CD;

resultsBoth occludin and claudin-1 were dysregulated in active disease, showing increased expression and cytoplasmic redistribution compared with remission and controls. TJ alterations were more pronounced in the CR and correlated with clinical, endoscopic, and histological activity. In CD, occludin CR overexpression was independently associated with hospitalization (aOR 1.010;

conclusionsTJ remodeling, particularly crypt-level occludin dysregulation, is associated with disease activity and clinical outcomes, capturing a clinically relevant dimension of epithelial barrier dysfunction in IBD.

Indexed as

Disease ProgressionInflammatory Bowel DiseasesTight JunctionsAdultClaudin-1Colitis, UlcerativeCrohn DiseaseFemaleHumansIntestinal Barrier FunctionIntestinal MucosaMaleMiddle AgedOccludinRetrospective StudiesClaudin-1Occludinbarrier dysfunctionclaudin-1clinical outcomesCrohn’s diseaseinflammatory bowel diseaseintestinal barrieroccludintight junctionulcerative colitis

Identifiers

PMID42041563
PMCPMC13114733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.