Evidence map›Paper›PMID 42041411›Full record

ReviewBiosensors2026

Recent Advances in Graphene-Based Field-Effect Transistor Biosensors for Disease Biomarker Detection and Clinical Prospects.

Deeksha Nagpal, Anup Singh, John Link, Abijeet Singh Mehta, Ashok Kumar, Vinay Budhraja

Abstract readReview
In one paragraph

Review in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. From Sensing Mechanisms to System Co-Design: Graphene-Based Sensors and Readout Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deeksha NagpalUniversity Centre for Research and Development, Chandigarh University, Mohali 140413, India.ORCID 0000-0003-1362-4632
Anup SinghUniversity Centre for Research and Development, Chandigarh University, Mohali 140413, India.ORCID 0000-0002-9282-0676
John LinkDepartment of Electrical Engineering, College of Engineering and Engineering Technology, Northern Illinois University, Dekalb, IL 60115, USA.
Abijeet Singh MehtaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78521, USA.ORCID 0000-0002-5759-1716
Ashok KumarDepartment of Applied Sciences, National Institute of Technical Teachers Training and Research, Chandigarh 160019, India.ORCID 0000-0001-9152-9062
Vinay BudhrajaDepartment of Electrical Engineering, College of Engineering and Engineering Technology, Northern Illinois University, Dekalb, IL 60115, USA.ORCID 0000-0002-0339-8953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Field-effect transistor (FET) biosensors using graphene have become one of the most promising biosensing platforms for the early diagnosis of diseases with features such as high sensitivity, label-free detection and application compatibility with point-of-care systems. Herein, we critically discuss recent advances in graphene FET (GFET) biosensor development toward clinically relevant biomarkers associated with representative diseases including cancer, neurodegenerative disease, infectious disease, and inflammatory conditions. Recent progress was reviewed to evaluate GFET architectures, surface functionalization methods, and detection quality. The biomarkers explored were clusterin in Alzheimer's disease, thrombin in coagulopathy, estrogen receptor α (ER-α) in breast cancer, Carcinoembryonic antigen in lung cancer, microRNAs for malignant tumors, exosomes derived from HepG2 for the hepatocellular carcinoma (HCC) cell line, interleukin-6 (IL-6) for chronic obstructive pulmonary disease (COPD), Polyclonal antibodies and antigens (P24) for HIV and prostate-specific antigen for prostate cancer. The developed devices demonstrate ultralow detection limits at femtomolar to attomolar concentrations with the aid of designed antibodies, aptamers and nanomaterials. Herein, this review presents the sensing mechanisms and biomedical application of various GFET platforms, focusing on their emerging potential as next-generation platforms for rapid, non-invasive and point-of-care diagnostics.

Indexed as

BiomarkersBiosensing TechniquesGraphiteTransistors, ElectronicHumansBiomarkersGraphitebiomarker detectionclusterincytokine IL-6estrogen receptor αgraphene field-effect transistorhepatocellular carcinomamicroRNAsprostate-specific antigenthrombin

Identifiers

PMID42041411
PMCPMC13113950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.