Evidence map›Paper›PMID 42041410›Full record

ArticleBiosensors2026

FAP-Anchored Retinoic Acid Nanoparticles for Stromal Reprogramming and Enhanced Intratumoral Oxaliplatin Delivery in Fibrotic Colorectal Tumours.

Haixia Wang, Can Xu, Ling Xie, Xiaohe Chu, Xinyu Liu, Peng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haixia WangCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Can XuCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Ling XieHangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China.
Xiaohe ChuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Xinyu LiuHangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China.
Peng WangHangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China.

Funding

China Postdoctoral Science Foundation 2024M763334
6 · The paper itself

Abstract

In colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) and the fibrotic stroma generate form a dense stromal barrier that restricts the intratumoural exposure and spatial distribution of oxaliplatin. To enable local stromal remodelling of this pathological stromal compartment, we selected fibroblast activation protein (FAP) as a stromal target and co-assembled two amphiphilic conjugates, oncoFAP and retinoic acid (RA), into an FAP-directed RA nanoformulation termed LRA

Indexed as

Colorectal NeoplasmsGelatinasesMembrane ProteinsNanoparticlesOxaliplatinSerine EndopeptidasesTretinoinAnimalsAntineoplastic AgentsCell Line, TumorEndopeptidasesFibroblast Activation Protein AlphaHumansMiceAntineoplastic AgentsEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsOxaliplatinSerine EndopeptidasesTretinoincancer-associated fibroblastcolorectal cancerextracellular matrixfibroblast activation proteinretinoic acid

Identifiers

PMID42041410
PMCPMC13115307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.