ReviewClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Review of Bleeding as Initial Presentation in Patients with Chronic Myeloid Leukemia.
Review in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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18 authors.
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Abstract
BackgroundChronic myeloid leukemia (CML) typically presents with fatigue, weight loss, leukocytosis, and splenomegaly. Major bleeding or spontaneous hematoma as the initial manifestation is rare and poses significant diagnostic and therapeutic challenges. This narrative review summarizes published cases of CML presenting first with bleeding or hematoma.MethodsA PRISMA-style literature search of PubMed, Embase, Scopus, and Web of Science (up to 8 November 2025) identified case reports and series in which bleeding, hemorrhage, or hematoma constituted the initial presentation leading to the diagnosis of CML. Extracted data included demographics, bleeding site, laboratory findings, management and outcomes.ResultsFifty-three patients were identified (median age 45 years; range 10-68), 74% male. Bleeding most commonly involved the central nervous system (40%), followed by soft-tissue/musculoskeletal hematomas (25%), intra-abdominal or visceral bleeding-predominantly splenic (19%)-and ocular/orbital hemorrhage (13%). Most patients had marked leukocytosis (median WBC ≈280 × 10
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