Evidence map›Paper›PMID 42041135›Full record

ArticleChembiochem : a European journal of chemical biology2026

Identification of Secondary Nucleation Inhibitors of Amyloid-β Aggregation by Cellular Selection of a SICLOPPS Library.

ByungUk Lee, Brian Flood, Emma Potter, Tina Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

ByungUk LeeDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Brian FloodDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Emma PotterDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tina WangDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-7259-7449

Funding

A high-throughput assay to measure amyloid-β oligomer formationR21AG088715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Tina Wang · 2024 to 2026
$582k
NIA NIH HHS R21 AG088715NIA NIH HHS R21AG088715
6 · The paper itself

Abstract

Alzheimer's disease is characterized by the accumulation of amyloid beta (Aβ) aggregates. Soluble oligomers Aβ oligomeric intermediates (AβOs) generated during aggregation are hypothesized to be a neurotoxic species. Many cyclic peptides have been developed to inhibit Aβ aggregation but primarily target Aβ monomers and fibrils; few cyclic peptides selectively recognize AβOs. We selected a library of >10

Indexed as

Amyloid beta-PeptidesPeptide FragmentsPeptide LibraryPeptides, CyclicAmino Acid SequenceHumansInteinsProtein AggregatesAmyloid beta-PeptidesPeptide FragmentsPeptide LibraryPeptides, CyclicProtein Aggregatesamyloidcyclic peptidespeptidesprotein aggregationsplit‐inteins

Identifiers

PMID42041135
PMCPMC13113203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.