Evidence map›Paper›PMID 42041067›Full record

ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2026

Survival and prognostic factors of parotid malignancies in Northern Italy: a multicentric study.

Giulia Molinari, Carla Cantaffa, Federica Spina, Francesco Mattioli, Daniele Marchioni, Francesco Maccarrone, Alfredo Lo Manto, Caterina Vaccari, Paolo Russo, Angelo Ghidini and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Giulia MolinariOtolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Carla CantaffaDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Federica SpinaDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Francesco MattioliDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Daniele MarchioniDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Francesco MaccarroneDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Alfredo Lo MantoDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Caterina VaccariDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Paolo RussoDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Angelo GhidiniOtorhinolaryngology Head and Neck Surgery Department, IRCCS Arcispedale Santamaria Nuova, Reggio Emilia, Italy.
Domenico MurriOtorhinolaryngology Head and Neck Surgery Department, IRCCS Arcispedale Santamaria Nuova, Reggio Emilia, Italy.
Cinzia Del GiovaneDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
Luigi ChiariniDepartment of Medical and Surgical Sciences for Children & Adults, Cranio-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, Modena, Italy.
Mattia Di BartolomeoDepartment of Medical and Surgical Sciences for Children & Adults, Cranio-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, Modena, Italy.
Pier Francesco NociniSurgery, Dentistry, Maternity and Infant Department, Unit of Dentistry and Maxillo-Facial Surgery, University of Verona, Verona, Italy.
Riccardo NociniUnit of Otolaryngology, Head and Neck Department, University of Verona, Verona, Italy.
Carlo CarosiOtolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Cecilia BottiOtolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Gabriele MolteniOtolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Livio PresuttiOtolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Matteo Alicandri-CiufelliDepartment of Otolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study is to report oncological outcomes of a multicentric cohort of surgically-treated parotid gland malignancies (PGMs) and compare them with other Italian Institutions. Methods: This is a retrospective multicentric study on surgically-treated patients with PGM. Overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) at 5 years were calculated. The Cox proportional hazard model was used for uni- and multivariate analyses. A qualitative review of the Italian literature was performed. Results: One-hundred and six patients were included. Negative prognostic factors included deep lobe involvement, size > 4 cm, advanced stage, margin status, histological grade, nodal involvement and extranodal disease. Parotidectomy extent did not influence DSS or DFS for T1-T2 superficial tumours. The occult lymph node metastasis rate was 30.8%. Neither elective neck dissection (END) nor elective neck irradiation (ENI) influenced DFS or DSS. Conclusions: Deep lobe removal in pT1-T2 superficial tumours may not always be necessary. END and ENI did not show a significant impact on prognosis, despite a high incidence of occult nodal metastasis. Further studies are needed to fully evaluate the impact of these therapeutic options in subgroups of patients with PGMs.

Indexed as

Parotid NeoplasmsAdolescentAdultAgedAged, 80 and overChildDisease-Free SurvivalFemaleHumansItalyLymphatic MetastasisMaleMiddle AgedNeck DissectionNeoplasm GradingNeoplasm Stagingdeep parotid lobeneck dissectionneck node metastasisparotid neoplasmsprognosis

Identifiers

PMID42041067
PMCPMC13113313

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.