ArticleActa otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale2026
Subtotal and total glossectomies with or without total laryngectomy - Does laryngeal preservation impact oncological and functional outcomes?
Article in Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Subtotal (SG) and total glossectomies (TG) represent surgical options for advanced oral and oropharyngeal squamous cell carcinomas (SCC). Associated laryngeal preservation maintains phonation but increases the risks of aspiration pneumonia and, potentially, local recurrence in the vallecular/supraglottic area. To mitigate these risks, SG/TG with total laryngectomy (TL) may be performed. This study evaluates functional and oncological outcomes of SG/TG with/without TL, focusing on the clinical impact of laryngeal preservation. Methods: This monocentric retrospective study analysed patients treated by SG/TG with/without TL between January 2013 and July 2024 in a referral, high-volume, academic institution. Oncological outcomes were assessed by overall (OS) and disease-free survival (DFS). Functional outcomes were evaluated in terms of gastrostomy- and tracheotomy-dependency. Results: Among 67 patients analysed, 56 (83.6%) underwent SG/TG without TL and 11 (16.4%) with TL. Gastrostomy-dependency at discharge was 83.6%, with minimal differences between laryngeal preservation (83.9%) and TL (81.8%). Tracheotomy-dependency in case of laryngeal preservation was 16.7% at 12 months. Five-year OS was 23.1%. No significant differences in terms of OS or DFS were observed between SG/TG with or without TL. Conclusions: Laryngeal preservation in SG/TG, when oncologically safe, does not worsen survival outcomes and offers better functional recovery. Gastrostomy dependency remains high across both groups, suggesting that laryngeal sacrifice does not confer significant nutritional advantages. State of the art reconstructive techniques using microvascular flaps facilitate laryngeal preservation without compromising survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.