ArticleRSC advances2026
Efficient aqueous solubilization of methylxanthines
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Caffeine, theophylline and theobromine are methylxanthines, a class of alkaloids present in coffee, tea and cocoa and therefore widely consumed all around the world. They exhibit several biological properties making them useful ingredients in cosmetics, as food additives or in pharmaceutical formulations. However, their solubility in water is limited. Extraction and purification often require the use of petrochemical volatile organic solvents. In the present paper, the solubility in water of caffeine, theophylline and theobromine in the presence of various natural solubilizing agents is reported. Niacinamide, as well as sodium or cholinium levulinate, salicylate, ferulate or caffeate were used to enhance the solubility of these methylxanthines in water. For example, solubility of theobromine was found to increase by a factor of 300 in aqueous solutions of ferulate salt. Solubilization mechanisms were investigated experimentally using
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