Evidence map›Paper›PMID 42040945›Full record

ArticleResearch square2026

Trust and task-sharing: the acceptability of nurses and peer educators in PrEP delivery among sexually and gender-diverse adolescents in Brazil.

Cristiane Spadacio, Lorruan Alves Dos Santos, Sarah MacCarthy, Katia Bruxvoort, Inês Dourado, Laio Magno, Paula Massa, Eudardo Araújo de Oliveira, Eliane Aparecida Sala, Marcia Thereza Cavalcanti Couto and 1 more

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In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristiane SpadacioUniversidade de São Paulo.
Lorruan Alves Dos SantosUniversidade de São Paulo.
Sarah MacCarthyUniversity of Alabama.
Katia BruxvoortUniversity of Alabama.
Inês DouradoUniversidade Federal da Bahia.
Laio MagnoUniversidade do Estado da Bahia.
Paula MassaUniversidade de São Paulo.
Eudardo Araújo de OliveiraUniversidade de São Paulo.
Eliane Aparecida SalaUniversidade de São Paulo.
Marcia Thereza Cavalcanti CoutoUniversidade de São Paulo.
Alexandre GrangeiroUniversidade de São Paulo.

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
NIAID NIH HHS P30 AI027767
6 · The paper itself

Abstract

Objectives: To examine the acceptability of oral and long-acting injectable PrEP (LAI-PREP) delivery by nurses and peer educators among sexual and gender diverse adolescents in Brazil. Design: A qualitative study using semi-structured interviews and reflexive thematic analysis. Setting: Community-based PrEP services in São Paulo and Salvador, Brazil, conducted within the PrEP15-19 demonstration study. Participants: Twenty PrEP clients aged 15-23 years (16 Black, 4 White; 14 cisgender men, 5 transgender or gender-diverse individuals) and nine healthcare staff (5 nurses, 2 peer educators, 2 physicians). Results: Trust emerged as the foundational element of PrEP engagement. Clients perceived nurses and physicians as having equivalent competence for prescribing PrEP though nurses were described as providing more comprehensive information. Support for peer-led prescription was mixed; most participants preferred peer involvement to remain focused on education and care navigation rather than clinical procedures. While LAI-PrEP was viewed positively, its technical requirements reinforced a preference for nurse-led delivery over peer involvement. Conclusions: Nurses are widely accepted as PrEP prescribers, while peer educators are valued primarily for their complementary, supportive roles. The introduction of LAI-PrEP may reinforce medicalized care models. To successfully implement differentiated PrEP delivery, programs must address professional hierarchies and prioritize the development of interdisciplinary teams.

Indexed as

AdolescentsBrazilHIV preventionKey populationsLong-acting injectable PrEPNursingPeer educatorsPre-exposure prophylaxis (PrEP)Qualitative research

Identifiers

PMID42040945
PMCPMC13105133

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.