Evidence map›Paper›PMID 42040896›Full record

ArticleHuman mutation2026

Cholesterol Reprograms Oxysterol Metabolism via the LOX1/CH25H/CYP7B1 Signaling Axis to Drive Multidrug Resistance in Colorectal Cancer.

Haixia Cheng, Luyao Huang, Jieshen Huang, Jiasheng Feng, Kehua Huang, Mei Liu, Ji Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haixia ChengLaboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Luyao HuangLaboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Jieshen HuangSchool of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.
Jiasheng FengSchool of Medicine, Tongji University, Shanghai, China, tongji.edu.cn.
Kehua HuangDepartment of Pediatric Surgery, Shenzhen Nanshan People's Hospital, Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, China.ORCID https://orcid.org/0009-0000-9122-0612
Mei LiuLaboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0000-0002-7364-6318
Ji LiDepartment of Gastrointestinal Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0009-0009-2491-4783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapeutic resistance remains a major contributor to tumor recurrence and unfavorable clinical outcomes in colorectal cancer (CRC). Although cholesterol metabolic reprogramming has been implicated in tumorigenesis, metastasis, and drug resistance across multiple malignancies, its specific role in CRC chemoresistance requires systematic investigation. We analyzed RNA-seq data from GEO dataset GSE196900 to identify differentially expressed genes (|Log2FC| ≥ 1.5, adjusted

Indexed as

CholesterolColorectal NeoplasmsCytochrome P450 Family 7Drug Resistance, NeoplasmOxysterolsScavenger Receptors, Class ESteroid HydroxylasesCell Line, TumorCell ProliferationFluorouracilGene Expression Regulation, NeoplasticHumansMetabolic ReprogrammingSignal TransductionCholesterolcholesterol 25-hydroxylaseCYP7B1 protein, humanCytochrome P450 Family 7FluorouracilOLR1 protein, humanOxysterolsScavenger Receptors, Class ESteroid HydroxylasesCH25H/CYP7B1 axischemoresistancecholesterolcolorectal cancermetabolic reprogramming

Identifiers

PMID42040896
PMCPMC13109663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.