Evidence map›Paper›PMID 42040893›Full record

ArticleHuman mutation2026

Transcriptomic Analysis Reveals the Role of

Conghua Song, Zijun Hou, Huifeng Wu, Xiaomei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Conghua SongGastrointestinal Endoscopy Center, The Affiliated Hospital of Putian University, Putian City, Fujian Province, China, ptu.edu.cn.ORCID https://orcid.org/0000-0002-1908-0640
Zijun HouCollege of Environmental and Biological Engineering, Putian University, Putian City, Fujian Province, China, ptu.edu.cn.ORCID https://orcid.org/0009-0009-7279-4536
Huifeng WuGastrointestinal Endoscopy Center, The Affiliated Hospital of Putian University, Putian City, Fujian Province, China, ptu.edu.cn.ORCID https://orcid.org/0009-0009-0025-2981
Xiaomei LiSchool of Basic Medicine, Putian University, Putian City, Fujian Province, China, ptu.edu.cn.ORCID https://orcid.org/0000-0002-0349-2392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatocellular carcinoma (HCC) shows high incidence and mortality worldwide. Methods: First, the differential expression of TRIM26 between tumor and normal tissues was analyzed using the TCGA dataset and cross-validated using TIMER 2.0 and HCCDB. Enrichment analysis evaluated its association with hallmark pathways including Wnt/ Results: TRIM26 was significantly upregulated in HCC tissues, and its high expression correlated with enrichment of oncogenic pathways including Wnt/ Conclusion: In HCC, TRIM26 was abnormally overexpressed. TRIM26 may regulate tumor progression via the Wnt/

Indexed as

Carcinoma, HepatocellularGene Expression ProfilingLiver NeoplasmsTranscriptomeTripartite Motif ProteinsUbiquitin-Protein LigasesWnt Signaling Pathwaybeta CateninComputational BiologyGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansTumor Microenvironmentbeta CateninTRIM26 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesHCCimmune infiltrationsingle-cell analysisTRIM26Wnt/β-catenin signaling pathway

Identifiers

PMID42040893
PMCPMC13108243

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.