ArticleFrontiers in medicine2026
Sleeve-fundoplication without gastric resection vs. sleeve gastrectomy: comparable weight loss with reduced GERD incidence in obese rats.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: Sleeve gastrectomy (SG) is a first-line bariatric procedure but may exacerbate gastroesophageal reflux disease (GERD) symptoms in obese patients. To mitigate this critical limitation, we developed a novel sleeve-fundoplication without gastric resection (SG-F) and investigated its efficacy and safety in a rat model of diet-induced obesity. Methods: A randomized controlled trial was conducted in twenty-four 8-week-old male SD obese rats, randomly assigned to the SG group ( Results: No statistically significant differences were observed in postoperative mortality or bleeding rates between the two groups. The incidence of postoperative GERD was significantly lower in the SG-F group than in the SG group (0% vs. 41.7%; Conclusion: SG-F achieves weight loss efficacy comparable to conventional SG without gastric resection, while suggesting improved anti-reflux protection and maintaining similar safety profiles in terms of mortality and bleeding. This novel procedure represents a promising alternative bariatric option for obese patients with GERD, avoiding the need for gastric tissue excision.
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