ArticleFrontiers in medicine2026
Comparison of postoperative deep vein thrombosis incidence between regional anesthesia with monitored anesthesia care and general anesthesia alone in total knee arthroplasty patients.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Total knee arthroplasty (TKA) is associated with a risk of postoperative deep vein thrombosis (DVT). While regional anesthesia is integral to multimodal analgesia protocols, its specific impact on DVT risk compared to general anesthesia remains unclear. Methods: This retrospective cohort study included 250 patients undergoing unilateral TKA. Based on anesthetic records, patients were categorized into a regional anesthesia with monitored anesthesia care group (RA group, Results: After matching, no significant difference was found in the overall incidence of postoperative DVT or symptomatic pulmonary embolism between groups ( Conclusion: With standardized pharmacologic prophylaxis, combined regional-general anesthesia did not further reduce the incidence of DVT after TKA compared to general anesthesia alone. Nonetheless, it provided significantly better analgesia, facilitated earlier functional recovery, shortened hospitalization, and lowered the risks of nausea, vomiting, and pulmonary complications. These findings support the inclusion of regional anesthesia as a key component for optimizing perioperative management in TKA patients.
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