ArticleFrontiers in medicine2026
Diagnostic utility of the urine neutrophil CD64 ratio for patients with urinary tract infections.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to evaluate the clinical significance of the urine neutrophil CD64 ratio for diagnosing urinary tract infections (UTIs). Methods: The study enrolled 106 patients suspected to have UTIs and 30 healthy controls. Based on urine culture results and clinical symptoms, 58 confirmed UTI patients with positive urine culture results and clinical symptoms were included in the urine culture positive (UCP) group, while 48 suspected UTI patients with negative urine culture results but positive clinical symptoms were included in the urine culture negative (UCN) group. Quantitative urine bacterial culture was used to identify pathogenic species and bacterial load. Urine leukocyte esterase (U-LE), urine nitrite (U-NIT), and urine leukocyte count (U-LC) were detected by an automatic urine analyzer. Neutrophil CD64 median fluorescence intensity (MFI) in urine and blood was measured by flow cytometry, and the ratio of neutrophil CD64 MFI in urine (U-nCD64) and blood (B-nCD64) was calculated. Results: Among the 58 urine bacterial isolates, Gram-negative bacteria were the predominant species (74.14%), with Conclusion: The U-nCD64 ratio has the higher auxiliary value for diagnosing UTIs and is more conducive for the screening and early diagnosis of UTIs. Thus, the U-nCD64 ratio might be a promising biomarker for auxiliary diagnosis of UTIs.
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