Evidence map›Paper›PMID 42040490›Full record

ArticleACS omega2026

Targeting Autoinducer‑2 Quorum Sensing: Novel Inhibitors Attenuate Virulence in

Angelica Pellegrini, Giorgio Milli, Elisa Bellan Menegussi, Simona Viglio, Pietro Cinaglia, Roberta Listro, Pasquale Linciano, Simona Collina, Giampiero Pietrocola

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angelica PellegriniDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.ORCID https://orcid.org/0009-0004-3339-3952
Giorgio MilliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
Elisa Bellan MenegussiDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.
Simona ViglioDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.
Pietro CinagliaDepartment of Health Sciences, University Magna Graecia, Italy; Data Analytics Research Center, University Magna Graecia, 88100 Catanzaro, Italy.
Roberta ListroDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0001-7615-1284
Pasquale LincianoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0003-0382-7479
Simona CollinaDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-2954-7558
Giampiero PietrocolaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, 27100 Pavia, Italy.ORCID https://orcid.org/0000-0002-7069-8155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic overuse has driven the development of bacterial drug resistance, highlighting the urgent need for new antimicrobial strategies. Quorum sensing, particularly via autoinducer-2 (AI-2) signal molecules, is a bacterial communication system involved in the development of drug resistance. Our recent work identified AI-2 inhibitors that disrupt biofilm formation in

Identifiers

PMID42040490
PMCPMC13103782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.