ArticleACS omega2026
Site-Specific Antigen Immobilization Improves Autoantibody Binding Efficiency on the Luminex Platform.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoantibodies (AABs) are valuable biomarkers for diagnosing and monitoring autoimmune diseases and cancer. Conventional AAB profiling methods, such as enzyme-linked immunosorbent assay and immunoblot, are time-consuming, labor-intensive, and limited in multiplexing capacity. Luminex xMAP technology overcomes these limitations by enabling high-throughput, multiplexed AAB detection via bead-based immunoassays. However, the random immobilization of antigens on Luminex beads can lead to suboptimal epitope exposure, reduced binding sensitivity, and inconsistent assay performance. This study examines whether oriented antigen immobilization via genetic code expansion and click chemistry enhances binding sensitivity on the Luminex platform compared to random immobilization via conventional amine coupling. We selected three human antigenic proteins, HDAC3, RPS17, and RPS4Y1, and incorporated the noncanonical amino acid (ncAA)
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.