Evidence map›Paper›PMID 42040484›Full record

ArticleACS omega2026

Cell Death Induced by Homoisoflavonoid Brazilin and Its Semisynthetic Derivatives on MDA-MB-231 and MCF7 Breast Cancer Cell Lines.

Miriam Zuñiga-Eulogio, Michael Quinteros, Alberto Hernández-Moreno, Tadeo Hernández-Moreno, Tapan Sharma, Monserrat Olea-Flores, Mario Ordóñez, Carla Coste-Sanchez, Teresita Padilla-Benavides, Napoleón Navarro-Tito

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miriam Zuñiga-EulogioFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Avenue Lázaro Cárdenas S/N Col. La Haciendita, Chilpancingo, Guerrero 39086, Mexico.ORCID https://orcid.org/0000-0003-2904-8350
Michael QuinterosDepartment of Molecular Biology and Biochemistry, Wesleyan University, 52 Lawn Avenue, Middletown, Connecticut 06459, United States.
Alberto Hernández-MorenoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Avenue Lázaro Cárdenas S/N Col. La Haciendita, Chilpancingo, Guerrero 39086, Mexico.
Tadeo Hernández-MorenoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Avenue Lázaro Cárdenas S/N Col. La Haciendita, Chilpancingo, Guerrero 39086, Mexico.
Tapan SharmaDepartment of Genetic and Cellular Medicine, University of Massachusetts Chan Medical School, 55 Lake Ave North, Worcester, Massachusetts 01605, United States.
Monserrat Olea-FloresFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Avenue Lázaro Cárdenas S/N Col. La Haciendita, Chilpancingo, Guerrero 39086, Mexico.
Mario OrdóñezCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Avenue Universidad 1001, Chamilpa, 62209 Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0000-0001-9395-7079
Carla Coste-SanchezDepartment of Chemistry, Wesleyan University, 52 Lawn Avenue, Middletown, Connecticut 06459, United States.
Teresita Padilla-BenavidesDepartment of Molecular Biology and Biochemistry, Wesleyan University, 52 Lawn Avenue, Middletown, Connecticut 06459, United States.ORCID https://orcid.org/0000-0002-4624-0822
Napoleón Navarro-TitoFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Avenue Lázaro Cárdenas S/N Col. La Haciendita, Chilpancingo, Guerrero 39086, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids are naturally occurring polyphenolic compounds that have been extensively explored as scaffolds for drug development due to their diverse biological activities. Brazilin, a homoisoflavonoid with reported antitumoral properties, does not fully meet pharmaceutical criteria, and chemical modification of natural compounds is often required to enhance bioactivity and efficacy. Here, we evaluated the proapoptotic activity of brazilin and its semisynthesized methoxylated (OMe)

Identifiers

PMID42040484
PMCPMC13103793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.