Evidence map›Paper›PMID 42040481›Full record

ArticleACS omega2026

14-Deoxy-11,12-didehydroandrographolide Promotes Ex Vivo Expansion of Umbilical Cord Blood Stem Cells through Stemness-Related Gene Regulation.

Laongthip Ruknarong, Nareerat Sutjarit, Nittaya Boonmuen, Puckjira Iaocharoen, Tippawan Duangsong, Wachirachai Pabuprapap, Apichart Suksamrarn, Duangrat Tantikanlayaporn

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laongthip RuknarongCenter of Excellence in Stem Research and Innovation, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.ORCID https://orcid.org/0000-0002-7205-8063
Nareerat SutjaritNutrition Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Nittaya BoonmuenDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Puckjira IaocharoenDepartment of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Tippawan DuangsongDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Wachirachai PabuprapapDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.ORCID https://orcid.org/0000-0001-6445-7550
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.ORCID https://orcid.org/0000-0001-8919-3555
Duangrat TantikanlayapornCenter of Excellence in Stem Research and Innovation, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.ORCID https://orcid.org/0000-0002-1197-4957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Umbilical cord blood (UCB) is a valuable alternative source of hematopoietic stem and progenitor cells (HSPCs) for allogeneic transplantation. However, the limited number of HSPCs that can be obtained from a single UCB unit remains a significant clinical challenge. Therefore, strategies to enhance the ex vivo expansion of functional HSPCs are of considerable interest. A key requirement for improving the success of HSC-based therapies, including transplantation and gene editing, is the ability to expand or preserve functional human HSCs during ex vivo culture. In this study, we demonstrate that 14-deoxy-11,12-didehydroandrographolide (14-DDA), a diterpenoid isolated from

Identifiers

PMID42040481
PMCPMC13103761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.