Evidence map›Paper›PMID 42040468›Full record

ArticleACS omega2026

Studies on a Sulfoxide-Bridged Tn Antigen Mimetic: Interaction with Macrophage Galactose Lectin and Inhibition of Sialyltransferase ST6GALNAC1.

Andrea Sodini, Emanuele Casali, Maria Alejandra Travecedo, Filipa Marcelo, Fabrizio Chiodo, Filippo Rambaldi, Sandra J van Vliet, Fabio Dall'Olio, Cristina Nativi

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea SodiniDepartment of Chemistry, DICUS, University of Florence, via della Lastruccia 3-13, Sesto Fiorentino 50019, Italy.
Emanuele CasaliDepartment of Chemistry, University of Pavia, via Taramelli 10, Pavia 27100, Italy.ORCID https://orcid.org/0000-0001-7501-5213
Maria Alejandra TravecedoUCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University Lisbon, Caparica 2829-516, Portugal.
Filipa MarceloUCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University Lisbon, Caparica 2829-516, Portugal.ORCID https://orcid.org/0000-0001-5049-8511
Fabrizio ChiodoBio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, via Campi Flegrei 34, Napoli 80078, Italy.
Filippo RambaldiDepartment of Chemistry, DICUS, University of Florence, via della Lastruccia 3-13, Sesto Fiorentino 50019, Italy.
Sandra J van VlietDepartment of Molecular Cell Biology and Immunology Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Fabio Dall'OlioDepartment of Medical and Surgical Sciences, DIMEC, University of Bologna, via San Giacomo 14, Bologna 40126, Italy.
Cristina NativiDepartment of Chemistry, DICUS, University of Florence, via della Lastruccia 3-13, Sesto Fiorentino 50019, Italy.ORCID https://orcid.org/0000-0002-6312-3230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant O-glycosylation is a defining hallmark of epithelial cancers, where truncated mucin-type glycans such as Tn and sialyl-Tn (sTn) are prominently displayed. Despite their tumor specificity, these tumor-associated carbohydrate antigens (TACAs) elicit only weak immune responses, limiting their impact in vaccine-based immunotherapy. Growing evidence implicates two major factors in this poor immunogenicity: the intrinsic engagement of Tn/sTn with the immunosuppressive macrophage galactose-type lectin (MGL) on antigen-presenting cells and the "self" nature of Tn/sTn mucin carriers such as MUC1. Both processes critically depend on the

Identifiers

PMID42040468
PMCPMC13103762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.