ArticleACS omega2026
Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
27 authors.
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Abstract
Despite the availability of vaccines and treatments for COVID-19, the emergence of new SARS-CoV-2 variants continues to challenge vaccine-induced immunity, emphasizing the need to develop antiviral therapies to combat these variants and other viruses. Umifenovir (UMF), marketed as Arbidol, is a broad-spectrum antiviral drug approved in Russia and China for influenza viruses A and B. Recent studies have suggested its potential against SARS-CoV-2, demonstrating its ability to inhibit viral replication and obstruct viral entry by targeting the spike protein, despite having low oral bioavailability and short half-life. In this work, we conducted an initial antiviral screening that identified a hit compound (a UMF analogue), followed by the rational design, synthesis, and evaluation of novel UMF derivatives against SARS-CoV-2. This process employed generative models and structure-activity relationship studies (SAR), focusing on the UMF binding site on the S2 subunit of the spike protein. The derivatives demonstrated potent antiviral activity, with EC
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