Evidence map›Paper›PMID 42040410›Full record

ArticleACS omega2026

From Hit to Lead: Systematic Optimization of the Quinazolinedione Scaffold as Potent and Noncytotoxic Antimalarial Agents.

Duangporn Lohawittayanan, Tachin Khulmanee, Kanthinich Thima, Napason Chabang, Wanchalerm Yenjai, Phongthon Kanjanasirirat, Patrick Schlaeppi, Varisa Tantivess, Tanadej Phumisithikul, Detchart Ratcha-In and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Duangporn LohawittayananInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Tachin KhulmaneeDrug Research Unit for Malaria (DRUM), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Kanthinich ThimaDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Napason ChabangInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Wanchalerm YenjaiInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.ORCID https://orcid.org/0000-0002-5871-7851
Phongthon KanjanasiriratDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Patrick SchlaeppiInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Varisa TantivessInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Tanadej PhumisithikulInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Detchart Ratcha-InInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Sanisorn ChotsriluechaInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Dhanita ChuchaisuwannasriInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Matthew PhanchanaDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Nattapon PinthongDepartment of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Rapatbhorn PatrapuvichDrug Research Unit for Malaria (DRUM), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Sitthivut CharoensutthivarakulInnovative Molecular Discovery Laboratory (iMoD), School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.ORCID https://orcid.org/0000-0002-4447-3438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of

Identifiers

PMID42040410
PMCPMC13103784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.