ArticleFrontiers in neuroscience2026
CRH neurons in the AM-ACC circuit drive chronic pain and anxiety comorbidity.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Chronic pain induces anxiety disorders through aberrant interactions between the limbic system and sensory pathways, forming refractory comorbidity. The anterior cingulate cortex (ACC), a key hub for integrating pain and emotion, contains corticotropin-releasing hormone (CRH) neurons closely associated with stress responses. However, the thalamic input mechanisms mediating the pain and anxiety comorbidity remain unclear. Here, through immunofluorescence staining, calcium imaging, neural circuit tracing, patch-clamp recording, and optogenetics- or chemogenetics-based manipulations, we re-veal that the anteromedial thalamic nucleus (AM), as a pivotal nucleus of the anterior thalamic group, specifically regulates ACC
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