ReviewJournal of translational autoimmunity2026
Immunologic links between cutaneous lupus and internal organ involvement in SLE: A systematic review and meta-analysis.
Review in Journal of translational autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Background: Cutaneous lupus erythematosus (CLE) represents one of the most frequent clinical manifestations of systemic lupus erythematosus (SLE), yet its relationship with internal organ involvement remains incompletely defined. Increasing evidence suggests that cutaneous inflammation may reflect systemic immune activation through dysregulated interferon signaling, immune complex deposition, and complement consumption. This systematic review and meta-analysis aimed to determine the association between CLE and major organ involvement in patients with SLE. Methods: A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published between 2014 and 2024. Observational studies assessing organ involvement among SLE patients with and without cutaneous manifestations were included. Two reviewers independently performed study selection, data extraction, and quality appraisal using the Newcastle-Ottawa Scale. A random-effects meta-analysis was conducted to estimate pooled odds ratios (OR) with 95% confidence intervals (CI) for renal, neuropsychiatric, hematologic, and cardiopulmonary involvement. Heterogeneity was quantified using I Results: Twenty-three studies met inclusion criteria for qualitative synthesis, and sixteen were eligible for quantitative pooling, comprising 8412 patients. Meta-analysis demonstrated that CLE was significantly associated with increased risk of lupus nephritis (OR 2.14, 95% CI 1.62-2.85), neuropsychiatric lupus (OR 1.78, 95% CI 1.29-2.46), and hematologic abnormalities (OR 1.95, 95% CI 1.40-2.71). A modest but significant association with cardiopulmonary involvement was also observed (OR 1.52, 95% CI 1.11-2.09). Subgroup analyses revealed stronger associations in acute CLE phenotypes and in patients with high interferon signatures. Sensitivity analyses confirmed robustness of findings, with no evidence of major publication bias. Conclusion: CLE is associated with significantly greater renal, neuropsychiatric, hematologic and cardiopulmonary involvement in patients with SLE compared with those without skin disease. These findings suggest that CLE is associated with increased systemic disease activity and a higher burden of internal organ involvement in SLE. CLE should therefore be considered an important clinical indicator of increased systemic risk in SLE.
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