ArticleNeurology. Genetics2026
Elicited Repetitive Daily Blindness Associated With Gain-of-Function
Article in Neurology. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026Review
- Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Elicited Repetitive Daily Blindness (ERDB) is a debilitating condition resulting in recurrent, daily episodes of reversible visual loss. ERDB has been described in individuals with Familial Hemiplegic Migraine 3 (FHM3), caused by pathogenic Methods: Data were collated through clinical interview and review of medical records for the probands of 4 new families with FHM3 and ERDB. Genetic analysis was performed for probands and, where possible, their parents. Whole-cell patch-clamp experiments were performed to measure sodium currents. Measurements were taken from transfected temperature sensitive SV40 Large T-antigen (tsA-201) cells and cortical GABAergic neurons in primary culture expressing the human Na Results: Four new pedigrees are described with typical FHM3 and ERDB (families 3-6). Blindness attacks commenced from infancy to 9 years of age. Episodes occurred 3-10 times per day, lasting up to 30 seconds. Genetic testing revealed novel heterozygous variants in the Discussion: Our study demonstrates that ERDB is a clinical feature in FHM3 patients because of gain-of-function Na
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.