Evidence map›Paper›PMID 42040240›Full record

ArticleRegenerative biomaterials2026

Paeoniflorin-loaded MBG nanogel alleviates oxidative microenvironment and reinforces subchondral bone regeneration for osteoarthritis treatment.

Zugui Wu, Xiuhong Huang, Jiao Li, Gaoquan Zheng, Feng Peng, Wei Dong, Yue Zhu, Yu Zhang, Rong Yuan, Zhiwei Wu and 3 more

Abstract read
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In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zugui WuThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Xiuhong HuangSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Jiao LiThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Gaoquan ZhengMedical Research Institute, Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Feng PengMedical Research Institute, Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.ORCID https://orcid.org/0000-0003-2366-2253
Wei DongThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Yue ZhuThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Yu ZhangMedical Research Institute, Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Rong YuanThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Zhiwei WuThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Ying GuoThe Third Clinical College of Yunnan University of Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650500, China.
Jin XiaoMedical Research Institute, Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Biaolin WanDepartment of Joint Surgery and Sports Medicine, Heyuan People's Hospital, Guangdong Provincial People's Hospital Heyuan Hospital, Heyuan 517100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) involves synergistic pathological changes in both cartilage degradation and subchondral bone remodeling due to oxidative stress, yet current therapies typically target these processes separately. To address this limitation, we developed a dual-functional nanogel (MBG@Pae@HA) by conjugating hyaluronic acid (HA) and paeoniflorin (Pae) to mesoporous bioactive glass nanoparticles via amide bonding and non-covalent interactions, respectively. Leveraging the inherent hydrophilicity of HA, MBG@Pae@HA spontaneously forms nanogels and shows enhanced adhesion force which ensure extended Pae and bioactive ions release in the OA microenvironment. MBG@Pae@HA exhibits potent reactive oxygen species (ROS)-scavenging capacity, contributing to the homeostatic balance between cartilage matrix anabolism and catabolism. Transcriptomic analysis revealed that MBG@Pae@HA treatment reactivates chondrocyte function through activating the cAMP/PKA/CREB antioxidant pathway. Furthermore, with controlled release of Pae and bioactive components (including Ca ions, Si ions and

Indexed as

articular cartilagenanogelosteoarthritispaeoniflorinROS scavengingsubchondral bone

Identifiers

PMID42040240
PMCPMC13106897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.