Evidence map›Paper›PMID 42040236›Full record

ArticleRegenerative biomaterials2026

Acellular nerve perineurium repairs peripheral nerve injuries in a rat model via ECM-mediated barrier and optimization of the regenerative microenvironment.

Fulin He, Zhenpeng Li, Fawei Liao, Shuihuan Wang, Xijun Huang, Jiahui Sun, Aijun Huang, Siyu LinFang, Tao Lin, Zilong Rao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fulin HeDepartment of Orthopaedics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, China.
Zhenpeng LiOrthopedic Center, Department of Orthopedics and Traumatology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China.
Fawei LiaoDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Shuihuan WangDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Xijun HuangDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Jiahui SunMedical Genetic Center, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou 510010, China.
Aijun HuangDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Siyu LinFangDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Tao LinDepartment of Orthopedics and Traumatology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, China.
Zilong RaoPCFM Lab, GD HPPC Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.ORCID https://orcid.org/0009-0003-0143-6068
Xiaolin LiuDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Shuo TangDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
Qingtang ZhuDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Canbin ZhengDepartment of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Shuai QiuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Building upon the clinically established platform of acellular nerve allografts (ANAs), we developed an advanced derivative: acellular nerve perineurium (ANP) grafts. These grafts are characterized by their preservation of the native perineurial barrier architecture and a unique extracellular matrix (ECM) composition, distinct from the endoneurial basement membrane. This distinctive ECM profile endows ANPs with significantly enhanced barrier integrity and robust neuroprotective properties.

Indexed as

acellular nerve perineuriumextracellular matrixnerve regenerationperipheral nerve injuryregenerative microenvironment

Identifiers

PMID42040236
PMCPMC13108856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.