ArticleJournal of microscopy and ultrastructure
Relation of Osteopontin Expression to Tumor-Associated Macrophages-Derived Transforming Growth Factor Beta 1 Expression in Non-small Cell Lung Carcinoma.
Article in Journal of microscopy and ultrastructure. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lung cancer is the most common cause of cancer death worldwide. Non-small lung carcinoma (NSCLC) is the most frequently encountered type Osteopontin (OPN) is a glycoprotein with multiple functions including malignant tumor propagation and invasion. Tumor-associated macrophages 2 (M2-TAMs) are crucial for malignant tumor invasion, they secrete several cytokines. One of these is transforming growth factor beta 1 (TGF-β1), a major immune suppressive cytokine. This work aimed to study the relation of OPN expression in tumor cells of NSCLC to M2-TAMs and their derived TGF-β1 expression and the association of these biomarkers' expression to clinicopathological factors. Materials and Methods: OPN expression, M2-TAMs, and their derived TGF-β1 expression were evaluated by immunohistochemical staining in 52 specimens of NSCLC. M2-TAMs were identified by staining with CD136. The immunohistochemical evaluation was performed semi-quantitatively according to the staining intensity and the percentage of stained cells. Results: OPN overexpression in tumor cells of NSCLC was significantly linked to spread through alveolar spaces (STAS), advanced Tumor (T) stage, and lymph node metastasis. Increased M2-TAMs infiltration (high CD163 score) and their expression of TGF-β1were associated with STAS, advanced T stage, and lymph node invasion. A positive correlation was found between OPN, CD163, and TGF-β1expression. Conclusion: OPN overexpression in tumor cells of NSCLC, high CD163 scores, and high TAM-derived TGF-β1 expression is significantly associated with adverse clinicopathological factors.
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