Evidence map›Paper›PMID 42040187›Full record

ArticleCyborg and bionic systems (Washington, D.C.)2026

Bioinspired Nanocomposite for Targeted Immunoengineering and Improved Tendon Regeneration.

Xianfeng Wang, Zhihong Xu, Yuwen Shangguan, Biyong Deng, Hao Nan, Zhecheng Jiang, Huan Li, Litao Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cyborg and bionic systems (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianfeng WangDepartment of Orthopedic Surgery, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang 550014, China.
Zhihong XuDivision of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing 210008, China.
Yuwen ShangguanDepartment of Orthopaedics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213003, China.
Biyong DengDepartment of Orthopedic Surgery, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang 550014, China.
Hao NanDepartment of Articular Orthopaedics, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Zhecheng JiangDepartment of Articular Orthopaedics, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Huan LiDepartment of Articular Orthopaedics, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Litao YanDepartment of Orthopaedics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon healing is impaired by excessive reactive oxygen species, inflammatory cell infiltration, and insufficient osteogenic differentiation during treatment. Therefore, simultaneously modulating the local inflammatory microenvironment and enhancing osteogenic regeneration are critical for effective tendon repair. Here, we designed a biomimetic nanoparticle system, macrophage-membrane-coated Prussian blue@kartogenin (KGN@PB@CM), loaded into a Pluronic@F127/hyaluronic acid (HA-F127) thermosensitive hydrogel. The HA-F127 hydrogel provides excellent hydrophilicity and enables sustained release of M-PB@KGN nanoparticles. Leveraging homologous targeting via the cell membrane, the KGN@PB@CM nanoparticles are efficiently delivered to macrophages, promoting their polarization toward a prohealing phenotype. Concurrently, KGN enhances the migration and differentiation of stem cells. Overall, we propose a "dual-modulation" strategy (anti-inflammatory and pro-osteogenic differentiation) to synergistically accelerate tendon healing.

Identifiers

PMID42040187
PMCPMC13103462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.