Evidence map›Paper›PMID 42040173›Full record

ArticleLymphatics2026

Pancreatic Lymphatics in Health and Disease: Evolution, Embryology, and Neural Control.

Alison Ross, Shakti Dahiya, Paulina Cabada Aguirre, Michael T Lotze, Jami L Saloman, Genia Dubrovsky

Abstract read
In one paragraph

Article in Lymphatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alison RossDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Shakti DahiyaDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Paulina Cabada AguirreHillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6073-9059
Michael T LotzeDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0003-3988-5419
Jami L SalomanHillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6093-6511
Genia DubrovskyDivision of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-1234-0382

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Peripheral Nerve Regulation of Pancreas Cancer ProgressionR01CA285585 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jami Lynn Saloman · 2024 to 2026
$1.9M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA285585
6 · The paper itself

Abstract

Diseases of the pancreas-such as pancreatic ductal adenocarcinoma (PDAC) and pancreatitis-have long been a challenge to treat. The study of lymphatics within the pancreas can provide some additional insights and offer new therapeutic targets. Here, we explore the development of pancreatic lymphatics and their connections to the nervous system and individual disease states, as well as the potential for therapeutic interventions. Lymphangiogenesis pathways in PDAC, driven by VEGF-C and other mediators, have been extensively explored, but specific therapeutic interventions are lacking. Furthermore, due to the emergence of PDAC with pancreatitis, insights could improve treatment in both settings. The role of neuroimmune interactions and control, as in other organ sites, appears as critical to both lymphatic and immune processes. With a better understanding of the lymphatic environment within the pancreas, we can develop more effective treatments for patients.

Indexed as

innervationlymphaticspancreaspancreatic ductal adenocarcinomapancreatitis

Identifiers

PMID42040173
PMCPMC13108687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.