An orally administrable hydrogen-bonded organic framework (HOF)-based nanoreactor to reprogram metabolism for senescence intervention.

Haochen Zhang, Junlin Ya, Jinsong Ren, Xiaogang Qu

Abstract read

In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haochen ZhangLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Junlin YaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Jinsong RenLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.ORCID https://orcid.org/0000-0002-7506-627X

Xiaogang QuLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.ORCID https://orcid.org/0000-0003-2868-3205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging poses significant health challenges due to functional decline and increased disease susceptibility. Modulating age-related metabolic dysregulation offers a promising therapeutic avenue. However, the efficacy of oral therapies is severely hampered by the degradation of active agents in the harsh gastrointestinal (GI) tract. Here, we report an orally administrable hydrogen-bonded organic framework (HOF)-based nanoreactor (MAO@NADH@PB@O-HOF@PEG) designed to intervene in senescence by modulating metabolic pathways. The HOF scaffold exhibits exceptional stability in ultra-acidic conditions and boiling water, providing a robust shield for its encapsulated delicate cargo against GI degradation. This protection enables prolonged

Indexed as

gut metabolomehydrogen-bonded organic frameworksoral catalytic therapysenescence

Identifiers

PMID42040162

DOI10.1093/nsr/nwag074

PMCPMC13105169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.