ReviewGalen medical journal2024
Narrative Review of Biomarkers in Patients with Peri-implantitis : Biomarkers in Patients with Peri-implantitis.
Review in Galen medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Salivary Oxidative Stress Biomarkers in Peri-Implant Disease: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peri-implantitis is caused by the breakdown of homeostasis between the host's response to microbial pathogens. The aim of this study was to assess clinical studies by use of a systematic review on some mouth biomarkers except of interleukin, active metalloproteinase (MMP) and TNF-α in peri-implantitis patients. Materials and Methods: A regular and complete search was conducted through mesh keywords by search of the Science Direct, PubMed, Google Scholar database until August 6, 2024. Those articles that reported biomarkers other than interleukin, MMP and TNF-α were included in this review. The outcome was defined to be peri-implantitis. Two reviewers have searched and screened the articles completely independently of each other. For assessing the quality of the studies, risk of bias tool developed by Downes et al. were used. Results: In general, 41 articles were found for this review. Based on our findings, key markers include Neutrophil extracellular traps (NETs), proinflammatory cytokines, oxidative stress markers, salivary biomarkers, microRNAs, extracellular vesicles, proteomic and metabolomic changes, and microbial markers. Stress markers like cortisol also play a role. Risk of bias is low in most studies. Conclusion: Biomarkers found in this study suggest a complex cascade of events involved in pathophysiological pathway of peri-implantitis including the microbial colonization, immune activation, bone resorption, oxidative stress, vascular changes, stress responses, and epigenetic modifications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.