ReviewGalen medical journal2024
The Impact of Systemic Drug Therapies (Bisphosphonates and Immunosuppressants) on Dental Implant Success: A Clinical Review.
Review in Galen medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of Medication Intake on Dental Implant-Related Outcomes-A Scoping Review.Clinical oral implants research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under normal physiological conditions, dental implants are a reliable and effective choice for tooth replacement with high success rates. However, compromised implant success is more closely related to systemic drug therapies like bisphosphonates and immunosuppressants used in patients.This review aims to identify key patterns of implant success and complications among patients undergoing long-term systemic drug therapy and provide clinical recommendations for optimizing outcomes. Bisphosphonates, especially in their intravenous (IV) forms, inhibit osteoclast activity and decrease bone turnover, which may negatively impact osseointegration and increase the incidence of osteonecrosis of the jaw (ONJ). Immunosuppressants are commonly associated with delayed wound healing and a higher risk of infection, complicating implant osseointegration due to their effect on the immune response. Clinicians must adopt personalized approaches to prevent complications in this patient population. Moreover, future studies should aim to explore the long-term effects of systemic drug therapies, particularly regarding dosages, treatment durations, combinations, and newer medications, while investigating drug interactions and dose-response relationships to provide more specific guidelines for clinicians on implant outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.