Evidence map›Paper›PMID 42039949›Full record

ArticleACS sustainable chemistry & engineering2026

Immobilized Hydroxymethylfurfural Oxidase Enables Robust Biocatalytic Production of 2,5-Furandicarboxylic Acid from Crude 5‑Hydroxymethylfurfural.

Darly Concha, Garazi Ortiz-Orruño, Marina Guillén, Oscar Romero, Kírian Bonet-Ragel

Abstract read
In one paragraph

Article in ACS sustainable chemistry & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Darly ConchaBioprocess Engineering and Applied Biocatalysis Group, Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Garazi Ortiz-OrruñoBioprocess Engineering and Applied Biocatalysis Group, Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID https://orcid.org/0000-0001-6013-7920
Marina GuillénBioprocess Engineering and Applied Biocatalysis Group, Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID https://orcid.org/0000-0002-9740-9966
Oscar RomeroBioprocess Engineering and Applied Biocatalysis Group, Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID https://orcid.org/0000-0002-0223-5167
Kírian Bonet-RagelBioprocess Engineering and Applied Biocatalysis Group, Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID https://orcid.org/0000-0002-0041-7493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioplastics such as poly-(ethylene 2,5-furandicarboxylate) (PEF), synthesized from biobased 2,5-furandicarboxylic acid (FDCA), offer a promising alternative to petrochemical-derived plastics. Enzymatic conversion of 5-hydroxymethylfurfural (HMF) to FDCA via hydroxymethylfurfural oxidase (HMFO) is environmentally benign but is limited by catalyst stability. This study addresses these challenges through a high-performance biocatalytic platform based on the one-step purification and immobilization of the engineered enzyme 8BxHMFO fused with a carbohydrate-binding module (CBM3). Utilizing the high affinity of CBM3 for microcrystalline cellulose (Perloza MT100), the biocatalyst achieved a significant increase in thermal stability (

Indexed as

2,5-furandicarboxylic acid (FDCA)5-hydroxymethylfurfural (HMF)biocatalysiscellulose-based supportsenzyme immobilizationhydroxymethylfurfural oxidase (HMFO)sustainable plastics

Identifiers

PMID42039949
PMCPMC13103917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.