SynthesisFrontiers in nutrition2026
The effect of immunonutrition on postoperative ileus following colorectal cancer surgery: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Objective: The effect of immunonutrition on postoperative gastrointestinal recovery in patients undergoing colorectal cancer surgery remains controversial. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of immunonutrition in alleviating postoperative ileus following colorectal cancer surgery. Methods: We searched PubMed, Web of Science, Embase, China National Knowledge Infrastructure, VIP, and Cochrane Library databases for eligible studies. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Results: A total of 28 RCTs involving 2,367 patients were included. Compared with the control group, immunonutrition supplementation significantly shortened the time to first flatus (MD, -0.56 days; 95% CI, -0.74, -0.39, Conclusion: Perioperative immunonutrition supplementation significantly shortened the time to first flatus and time to first defecation after colorectal cancer surgery. Further large-scale, multicenter RCTs are warranted to confirm these findings and establish optimal supplementation protocols. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251250520, CRD420251250520.
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