Evidence map›Paper›PMID 42039883›Full record

ArticleFrontiers in nutrition2026

Mohammed Abusidu, Yamina Alioui, Lara Al-Tibi, Dhafer Alwayli, Sharafat Ali, Mujeeb Ur Rahman, Nabeel Ahmed Farooqui, Aamna Atta, Bin Feng, Shuming Lu and 1 more

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In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Novel Hydrophilic Colloidal Polysaccharide fromFoods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohammed Abusidu *Department of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Yamina Alioui *Department of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Lara Al-TibiDepartment of Laboratory Medicine Sciences, College of Medicine Faculty of Medical Sciences, Al-Aqsa University, Gaza, Palestine.
Dhafer AlwayliDepartment of Pathogen Biology and Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning Province, China.
Sharafat AliDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Mujeeb Ur RahmanDepartment of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Nabeel Ahmed FarooquiDepartment of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Aamna AttaDepartment of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Bin FengDepartment of Biotechnology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning Province, China.
Shuming LuDepartment of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Liang WangDepartment of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chemotherapy-induced intestinal mucositis is a frequent and debilitating complication of anticancer treatment, particularly with cisplatin, leading to disruption of the epithelial barrier, inflammation, and dysbiosis of the gut microbiota. Natural polysaccharides with antioxidant and immunomodulatory properties have attracted increasing attention as potential protective agents. This study investigated the protective effects of Methods: HMP were extracted and structurally characterized through monosaccharide composition and molecular weight analysis. Antioxidant activity was evaluated using the ABTS Results: HMP were obtained at a yield of 16% and consisted mainly of glucose (52.44%) and galactose (21.05%), together with other monosaccharides, with a molecular weight of 752.96 kDa. Discussion: These findings indicate that HMP protects against cisplatin-induced intestinal mucositis through multiple complementary mechanisms, including antioxidant activity, suppression of inflammatory responses, preservation of epithelial barrier integrity, and modulation of gut microbiota composition. HMP therefore represents a promising natural candidate for mitigating chemotherapy-induced gastrointestinal toxicity.

Indexed as

16S rRNA sequencingcisplatingut microbiota dysbiosisHypsizygus marmoreusintestinal mucositispolysaccharidessystemic inflammation

Identifiers

PMID42039883
PMCPMC13108610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.