ArticleFrontiers in neuroimaging2026
Electroconvulsive therapy modulates Fronto-temporal functional connectivity in adolescents with depression and suicidal ideation.
Article in Frontiers in neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: We aimed to investigate changes in whole-brain functional connectivity (FC) before and after electroconvulsive therapy (ECT) in adolescents with major depressive disorder (MDD) and suicidal ideation (SI). Methods: Forty-nine adolescents with MDD and SI were enrolled, and resting-state functional magnetic resonance imaging (rs-fMRI) was performed at baseline and after ECT for each patient. Forty healthy controls (HCs) were scanned only at baseline. Region-of-interest (ROI)-based whole-brain FC analyses were used, with the left superior frontal gyrus (L-SFG) and right superior temporal gyrus (R-STG) as seed regions. Results: Compared with HCs, MDD patients at baseline showed decreased FC between R-STG and left inferior occipital gyrus (L-IOG), and between L-SFG and right anterior cingulate gyrus (R-ACG). After ECT, MDD patients showed reduced FC between R-STG and right middle temporal gyrus (R-MTG), increased FC between L-SFG and right middle frontal gyrus (R-MFG), and decreased FC between L-SFG and right superior occipital gyrus (R-SOG)/right superior frontal gyrus (R-SFG). Pearson's correlation found that post-ECT Hamilton Depression Rating Scale-17 (HAMD-17) scores were negatively correlated with FC between R-STG and L-IOG. Conclusion: Abnormal FC in the frontal-cingulate and frontal-temporal circuits may be a potential neurobiological basis of depressive and suicidal symptoms in adolescents. ECT may improve these symptoms by modulating FC in these key brain regions.
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