ArticleFrontiers in microbiology2026
A novel GntR-ABC efflux system mediates oxidative stress response, drug resistance, motility and virulence in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: In this study, we characterized the role of the GntR family transcriptional regulator AUO97_RS16340 and its associated ABC efflux pump (AUO97_RS16355-RS16360-RS16365), previously identified as part of the OxyR regulon. Results: Through gain- and loss-of-function analyses, we demonstrate that this GntR regulator positively regulates the expression of the adjacent ABC efflux pump and plays a critical role in tolerance to H Discussion: Our findings reveal a new efflux system that links oxidative stress adaptation, efflux-mediated antimicrobial susceptibility, and pathogenicity in
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