ArticleFrontiers in microbiology2026
Molecular genetic characterization of a novel HIV-1 circulating recombinant form (CRF205_0107) among men who have sex with men in Hangzhou, China.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Circulating recombinant forms (CRFs) play a critical role in the global transmission of HIV-1. In China, where CRF01_AE and CRF07_BC are the predominant circulating strains, second-generation recombinant viruses derived from these two CRFs are continually emerging. This study identified a novel CRF derived from CRF01_AE and CRF07_BC, designated CRF205_0107, and analyzed its genomic structure, parental lineages, and coreceptor usage. Methods: A dataset of HIV-1 Results: Four HIV-1 NFLGs were obtained. BLAST analysis revealed that a previously reported NFLG sequence (Accession No. OP921950) from a man who has sex with men (MSM) individual in Hebei Province shared 98% similarity. Phylogenetic analysis demonstrated that these sequences formed a distinct monophyletic clade with 100% bootstrap support. Recombination analysis indicated that all five genomes shared a highly similar recombination pattern. Sub-regional phylogenetic analysis revealed that segments derived from CRF01_AE and CRF07_BC all clustered with the lineage associated with Chinese MSM (CRF01_AE_C4, CRF07_BC_N). Bayesian analysis estimated that CRF205_0107 originated around 2017-2018. Coreceptor tropism analysis based on the V3 loop indicated that all five NFLGs were CXCR4-tropic. Discussion: The emergence of CRF205_0107 provides further evidence that second-generation HIV-1 recombinants involving CRF01_AE and CRF07_BC are frequently generated in China, reflecting an increasingly complex HIV-1 epidemic among MSM populations. This complexity may further drive the accelerated spread of HIV-1. These findings underscore the importance of strengthening the identification and molecular epidemiological surveillance of CRF01_AE/CRF07_BC recombinant viruses, and highlight the urgency of curbing HIV-1 transmission among MSM in China.
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