Evidence map›Paper›PMID 42039805›Full record

ArticleFrontiers in microbiology2026

Immune priming reshapes the microbiota and modulates pathogen dynamics in the Manila clam (

Bruno K Rodino-Janeiro, Diego Rey-Varela, Ana L Dieguez, Sergio Rodriguez, Clara Martinez, Javier Dubert

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bruno K Rodino-Janeiro *Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, A Coruña, Spain.
Diego Rey-Varela *Department of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), CIBUS bldg-Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Ana L DieguezDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), CIBUS bldg-Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Sergio RodriguezDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), CIBUS bldg-Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Clara MartinezDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), CIBUS bldg-Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Javier DubertDepartment of Microbiology and Parasitology, Aquatic One Health Research Center (ARCUS), CIBUS bldg-Faculty of Biology, University of Santiago de Compostela, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invertebrates lack adaptive immunity and rely exclusively on innate defenses to combat pathogens. Recent studies have shown that invertebrates exhibit immune priming, a form of innate immune memory in which prior pathogen exposure enhances protection against reinfections. Despite its ecological and applied relevance, immune priming remains poorly explored in marine invertebrates. Most studies adopt a host-centric view, focusing on the immune response while overlooking that immunity occurs within a complex microbial context in which the host, its microbiota, and pathogens interact. This gap limits our understanding of how microbiota and pathogens behave under priming pressure. Here, we investigated the effects of immune priming on host survival, pathogen dynamics, and microbiota composition in the Manila clam (

Indexed as

bivalve aquacultureimmune primingmicrobiota shiftspathogen dynamicsRuditapes philippinarumVibrio europaeusvibriosis

Identifiers

PMID42039805
PMCPMC13106551

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.