Enantioselective organocatalytic radical alkylation enabled by photoexcitation.

Yanji Song, Ruifeng Wang, Xi Lu, Yuqiao Zhou, Xiaoming Feng, Weidi Cao, Xiaohua Liu

Abstract read

In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yanji SongKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.

Ruifeng WangKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.

Xi LuKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.

Yuqiao ZhouKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.ORCID https://orcid.org/0000-0003-3490-4182

Xiaoming FengKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.ORCID https://orcid.org/0000-0003-4507-0478

Weidi CaoKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.ORCID https://orcid.org/0000-0003-1440-4682

Xiaohua LiuKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University Chengdu 610064 China liuxh@scu.edu.cn wdcao@scu.edu.cn.ORCID https://orcid.org/0000-0001-9555-0555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoinduced single-electron transfer generates radicals that could engage in radical-radical cross-coupling reactions, but organocatalytic photocatalyst-free systems for enantioselective processes remain rare and challenging. Herein, we report a light-driven enantioselective alkylation of 3-hydroxyoxindoles with NHPI esters, providing a new route for a variety of 3-alkyl-3-hydroxy oxindole derivatives. The reaction follows a light-driven electron transfer/radical cross-coupling process by using a readily available chiral guanidine organocatalyst and PPh

Identifiers

PMID42039781

DOI10.1039/d6sc00272b

PMCPMC13104252

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.