Evidence map›Paper›PMID 42039706›Full record

ArticleMedComm2026

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.

Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Rongli FangClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Wei WangDepartment of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.
Li ZhangClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Jiwei HuangDepartment of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Lei HuangClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Huibo WuDepartment of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.
Yuyin QiClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Lili LiClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Liren TanClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Min ZhangDepartment of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.
Jianheng ZhuClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Xiang PengDepartment of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.
Kanghua ZhongClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Ming ZouClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Xi YangDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China.
Qiuhua WangDepartment of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Changjun NieDepartment of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Chaorui TangDepartment of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Ning TangDepartment of Comprehensive Experimental Center Guangxi Clinical Research Center for Obstetrics and Gynecology Liuzhou Hospital of Guangzhou Women and Children's Medical Center Liuzhou China.
Lanlan GengClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Hanhan ChenClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
James E VinceThe Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology University of Melbourne Parkville, Vic Australia.
Hirokazu KaneganeDepartment of Child Health and Development Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU) Tokyo Japan.
Xiaodong ZhaoDepartment of Rheumatology and Immunology Children's Hospital of Chongqing Medical University Chongqing China.
Huifang XianClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Wenhao ZhouClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Min ZhiDepartment of Gastroenterology and Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-Sen University Guangzhou China.
Yuxia ZhangClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.
Zhanghua ChenClinical Research Center For Pediatric Infection and Immunity and Department of Gastroenterology Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A substantial proportion of patients with X‑-linked inhibitor of apoptosis (XIAP) deficiency develop severe and treatment‑-refractory Crohn's disease (CD). Although hematopoietic stem cell transplantation (HSCT) remains the only curative option for these patients, its outcomes are suboptimal, with a long‑-term survival rate of only 50%. Therefore, identifying novel therapeutic targets is crucial to bridge this unmet clinical need. Here, we demonstrate that the abundance of tuft cells is reduced in both XIAP-deficient CD patients and

Indexed as

Crohn's diseaseJAK inhibitiontuft cellWnt/β‑catenin–ASCL2XIAP deficiency

Identifiers

PMID42039706
PMCPMC13109868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.