ReviewEnvironmental epigenetics2026
Epigenetic mechanisms linking hexavalent chromium exposure to pancreatic cancer risk: a systematic review.
Review in Environmental epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Pancreatic cancer remains one of the most lethal malignancies, largely due to late diagnosis and limited treatment options. Hexavalent chromium (Cr(VI)) is a well-established environmental and occupational carcinogen, and emerging epidemiological observations have raised questions about its potential involvement in cancers beyond the lung. This systematic review synthesizes current evidence on the epigenetic effects of Cr(VI) exposure, including DNA methylation, histone modifications, and microRNA dysregulation, and evaluates whether these mechanisms converge on pathways relevant to pancreatic carcinogenesis. A structured literature search of EMBASE and PubMed (including MEDLINE) identified 11 studies that met predefined inclusion criteria. Across these studies, Cr(VI) exposure was consistently associated with hypermethylation of tumour suppressor genes (including
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.