Evidence map›Paper›PMID 42039670›Full record

ArticlebioRxiv : the preprint server for biology2026

Not so cold after all: tumor infiltrating CD8+ T cells in EBV-positive Burkitt lymphoma are quiescent, not exhausted.

Catherine S Forconi, Cliff I Oduor, Priya L Saikumar, Zachary J Racenet, Gavin Fujimori, Viriato M'Bana, Angela Matta, Jeni Melo, Fabienne Läderach, Titus K Maina and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Catherine S ForconiDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-7358-5546
Cliff I OduorDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Priya L SaikumarDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Zachary J RacenetDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Gavin FujimoriDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Viriato M'BanaDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Angela MattaDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jeni MeloDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Fabienne LäderachDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Switzerland.
Titus K MainaDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Juliana A OtienoJaramogi Oginga Odinga Teaching and Referral Hospital, Kisumu, Kenya.
Chepsiror DanMoi Teaching and Referral Hospital, Eldoret, Kenya.
Kibet KiborMoi Teaching and Referral Hospital, Eldoret, Kenya.
Festus NjugunaMoi Teaching and Referral Hospital, Eldoret, Kenya.
Terry VikDepartment of Pediatric Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ann W KinyuaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Christian MünzDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Switzerland.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Ann M MoormannDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1113-2829

Funding

Impact of malaria on shaping immunity to EBV in the etiology of Burkitt lymphomaR01CA189806 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOORMANN, ANN M · 2014 to 2024
$5.7M
NCI NIH HHS R01 CA189806
6 · The paper itself

Abstract

Survival outcomes for pediatric Burkitt lymphoma (BL) substantially vary depending on geography (50-90%), which also serves as a proxy for the prevalence of Epstein-Barr virus (EBV) within the tumors. Although BL is considered an immunologically "cold" tumor with few tumor-infiltrating lymphocytes (TILs), their functional status has not been fully evaluated, especially for EBV-positive disease. Here, we characterize the exhaustion and activation profiles of T cells in the tumor microenvironment (TME) of EBV-positive BL using orthogonal methods, single-cell gene expression analysis, spectral flow cytometry, and immunohistochemistry staining (IHC). We found that CD8+ TILs displayed a mosaic of immune inhibitory gene expression encoding,

Indexed as

Burkitt lymphomaEpstein-Barr virusKenyasingle cell RNA sequencingtumor infiltrating lymphocytestumor microenvironment

Identifiers

PMID42039670
PMCPMC13104861

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.