Evidence map›Paper›PMID 42039665›Full record

ArticlebioRxiv : the preprint server for biology2026

Using Virtual Patients to Predict Perceptual Outcomes for Optogenetic Sight Recovery Technologies.

Vaishnavi B Mohan, Ezgi Irmak Yucel, Ione Fine, Geoffrey Boynton

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vaishnavi B MohanDepartment of Psychology, University of Washington, Seattle, WA.ORCID 0009-0001-0459-1982
Ezgi Irmak YucelDepartment of Psychology, University of Washington, Seattle, WA.ORCID 0000-0001-9768-9649
Ione FineDepartment of Psychology, University of Washington, Seattle, WA.ORCID 0000-0002-0142-7239
Geoffrey BoyntonDepartment of Psychology, University of Washington, Seattle, WA.ORCID 0000-0001-6561-6920

Funding

Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologiesR01EY031312 · NEI · UNIVERSITY OF WASHINGTON · PI BOYNTON, GEOFFREY M, FINE, IONE · 2021 to 2025
$2.0M
NEI NIH HHS R01 EY031312
6 · The paper itself

Abstract

Optogenetics is emerging as a powerful approach for partial vision restoration, with at least three ongoing clinical trials in humans testing novel light-sensitive proteins (opsins) in patients with inherited retinal degenerative disorders. These therapies aim to restore light responsiveness by introducing opsins into surviving retinal cells, such as bipolar or ganglion cells, enabling them to generate neural activity in response to visual stimuli. One ongoing difficulty in selecting promising opsins for clinical development is that there is no way to predict patient perceptual outcomes from optogenetically evoked neural activity as measured

Indexed as

Macular DegenerationOptogeneticsPerceptionPsychophysicsRetinitis PigmentosaVision RestorationVisual prostheses

Identifiers

PMID42039665
PMCPMC13104996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.