Evidence map›Paper›PMID 42039624›Full record

ArticlebioRxiv : the preprint server for biology2026

Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging.

Bruce Zhang, Kuei Ching Hsiung, Reva Biju, Marybelle Cameron-Pack, Xiaoya Wei, Hannah Chapman, Melisa Kelaj, Aihan Zhang, Chiminh Nguyen Hong, Collin Y Ewald and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bruce ZhangInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.ORCID 0000-0003-0956-6142
Kuei Ching HsiungInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Reva BijuInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Marybelle Cameron-PackInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Xiaoya WeiInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Hannah ChapmanInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Melisa KelajInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Aihan ZhangInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Chiminh Nguyen HongInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.
Collin Y EwaldDepartment of Health Sciences and Technology, ETH Zürich, Schwerzenbach, Switzerland.
David GemsInstitute of Healthy Aging, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.ORCID 0000-0002-6653-4676

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440Wellcome Trust
6 · The paper itself

Abstract

Reduced insulin/IGF-1 signaling (IIS) can greatly extend lifespan in

Indexed as

Agingantagonistic pleiotropyC. elegansgerospanGompertz equationhealthspaninsulin/IGF-1 signallinglifespanStrehler-Mildvan correlation

Identifiers

PMID42039624
PMCPMC13104923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.