Evidence map›Paper›PMID 42039606›Full record

ArticlebioRxiv : the preprint server for biology2026

Classical HLA Allele and Haplotype Frequency Estimates in US Populations.

Loren Gragert, Abeer Madbouly, Pradeep Bashyal, Kim Wadsworth, Jane Kempenich, Yung-Tsi Bolon, Martin Maiers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Loren GragertTulane University School of Medicine, Department of Medicine, Division of Biomedical Informatics and Genomics, New Orleans LA.
Abeer MadboulyCIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN.
Pradeep BashyalCIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN.
Kim WadsworthNMDP, Minneapolis, MN.
Jane KempenichNMDP, Minneapolis, MN.
Yung-Tsi BolonCIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN.
Martin MaiersCIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN.

Funding

Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
The landscape of HLA mediated variation in health and immunityR01AI158861 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$3.5M
HLA Immunogenetics and kidney allograft outcomesR01AI173095 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Malek Kamoun · 2023 to 2026
$3.1M
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN StudiesU01AI152960 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KAMOUN, MALEK, KEATING, BRENDAN JAMES · 2020 to 2024
$2.8M
Designing ABO-Compatible US Kidney Allocation - Resubmission - 1R01DK140336 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOREN GRAGERT, Michal A Mankowski · 2025 to 2026
$1.7M
NIAID NIH HHS R01 AI128775NIAID NIH HHS R01 AI158861NIAID NIH HHS R01 AI173095NIAID NIH HHS U01 AI152960NIDDK NIH HHS R01 DK140336
6 · The paper itself

Abstract

The human leukocyte antigen (HLA) system is the primary determinant of donor selection in allogeneic hematopoietic cell transplantation (HCT) and plays a central role in solid organ transplantation, immune-mediated disease studies, evolutionary population genetics, and immunotherapy. Large-scale sampling of registry participants reflecting major US ancestry groups allows for characterization of the complex landscape of HLA haplotype diversity for the classical HLA class I (HLA-A, HLA-B, HLA-C) and HLA class II (HLA-DRB1

Identifiers

PMID42039606
PMCPMC13104989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.