ArticlebioRxiv : the preprint server for biology2026
Quantifying Mg
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
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Abstract
RNA structural heterogeneity is increasingly recognized as essential for RNA function, yet quantitative understanding of intrinsic RNA structural dynamics and how cellular conditions modulate these dynamics remains limited. 7SK RNA is an abundant eukaryotic noncoding RNA that assembles with protein cofactors to form the 7SK ribonucleoprotein (RNP), a dynamic complex that regulates transcription elongation. In particular, the 7SK RNA stem-loop 3 (SL3) domain is a critical hub for protein recruitment that is required for 7SK RNP function. We recently discovered that SL3 undergoes exchange between two equally populated yet structurally distinct conformers, named SL3e and SL3a, providing a model system to understand RNA conformational equilibria. Here, we combined quantitative dimethyl sulfate mutational profiling with sequencing (qDMS-MaPseq), solution NMR spectroscopy, and isothermal titration calorimetry (ITC) experiments to gain quantitative insights into SL3 equilibria under varying ionic conditions. We find that Mg
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